Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander

MA, Ingber DE (2012) A human disease model of drug toxicity-induced pulmonary edema in a

lung-on-a-chip microdevice. Sci Transl Med 4(159):159ra147. https://doi.org/10.1126/

scitranslmed.3004249

Isoherranen N, Madabushi R, Huang SM (2019) Emerging role of organ-on-a-chip technologies in

quantitative clinical pharmacology evaluation. Clin Transl Sci 12(2):113–121. https://doi.org/

10.1111/cts.12627

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno

MA, Louden CS, Hamilton GA, Flaumenhaft R (2018) Primary human lung alveolus-on-a-chip

model of intravascular thrombosis for assessment of therapeutics. Clin Pharmacol Ther 103(2):

332–340. https://doi.org/10.1002/cpt.742

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Ingber DE

(2019) A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat

Biomed Eng 3:520–531. https://doi.org/10.1038/s41551-019-0397-0

Jang KJ, Suh KY (2010) A multi-layer micro fluidic device for efficient culture and analysis of renal

tubular cells. Lab Chip 10(1):36–42. https://doi.org/10.1039/B907515A

Jang KJ, Mehr AP, Hamilton GA, McPartlin LA, Chung S, Suh KY, Ingber DE (2013) Human

kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol

5(9):1119–1129. https://doi.org/10.1039/c3ib40049b

Jansen J, Fedecostante M, Wilmer MJ, Peters JG, Kreuser UM, Van Den Broek PH, Mensink RA,

Boltje TJ, Stamatialis D, Wetzels JF, Van den Heuvel LP (2016) Bioengineered kidney tubules

efficiently excrete uremic toxins. Sci Rep 6(1):26715. https://doi.org/10.1038/srep26715

Jing B, Wang ZA, Zhang C, Deng Q, Wei J, Luo Y, Zhang X, Li J, Du Y (2020) Establishment and

application of peristaltic human gut-vessel microsystem for studying host–microbial interaction.

Front Bioeng Biotechnol 8:272. https://doi.org/10.3389/fbioe.2020.00272

Kačarević ŽP, Rider PM, Alkildani S, Retnasingh S, Smeets R, Jung O, Ivanišević Z, Barbeck M

(2018) An introduction to 3D bioprinting: possibilities, challenges, and future aspects. Materials

11(11):2199. https://doi.org/10.3390/ma11112199

Kamei KI, Kato Y, Hirai Y, Ito S, Satoh J, Oka A, Tabata O (2017) Integrated heart/cancer on a chip

to reproduce the side effects of anti-cancer drugs in vitro. RSC Adv 7(58):36777–36786. https://

doi.org/10.1039/c7ra07716e

Kilian D, Ahlfeld T, Akkineni AR, Bernhardt A, Gelinsky M, Lode A (2020) 3D bioprinting of

osteochondral

tissue

substitutes–in

vitro-chondrogenesis

in

multi-layered

mineralized

constructs. Sci Rep 10:8277. https://doi.org/10.1038/s41598-020-65050-9

Kim IG, Park SA, Lee SH, Choi JS, Cho H, Lee SJ, Kwon YW, Kwon SK (2020) Transplantation of

a 3D-printed tracheal graft combined with iPS cell-derived MSCs and chondrocytes. Sci Rep 10:

4326. https://doi.org/10.1038/s41598-020-61405-4

Kimura H, Sakai Y, Fujii T (2018) Organ/body-on-a-chip based on microfluidic technology for

drug discovery. Drug Metab Pharmacokinet 33(1):43–48. https://doi.org/10.1016/j.dmpk.2017.

11.003

Langhans SA (2018) Three-dimensional in vitro cell culture models in drug discovery and drug

repositioning. Front Pharmacol 9:6. https://doi.org/10.3389/fphar.2018.00006

Lee J, Kim K, Kim S (2018) Kidney on chips. Methods Cell Biol 146:85–104. https://doi.org/10.

1016/bs.mcb.2018.06.001

Leucht A, Volz AC, Rogal J, Borchers K, Kluger PJ (2020) Advanced gelatin-based vascularization

bioinks for extrusion-based bioprinting of vascularized bone equivalents. Sci Rep 10:5330.

https://doi.org/10.1038/s41598-020-62166-w

Maschmeyer I, Lorenz AK, Schimek K, Hasenberg T, Ramme AP, Hubner J et al (2015) A four-

organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney

equivalents. Lab Chip 15:2688–2699. https://doi.org/10.1039/c5lc00392j

Mengus C, Muraro MG, Mele V, Amicarella F, Manfredonia C, Foglietta F (2017) In vitro

modeling of tumor-immune system interaction. ACS Biomater Sci Eng 4(2):314–323. https://

doi.org/10.1021/acsbiomaterials.7b00077

94

G. Aggarwal et al.